Under normal circumstances, our intestines are colonized by hundreds of species of microbes, collectively termed the microbiota. Our intestines can also be colonized by macroscopic organisms, such as parasitic worms (helminths). The presence of particular microbes or macrobes within the intestinal tract can drastically alter the development and functioning of our immune system, which in turn can influence our susceptibility to infectious, inflammatory and allergic diseases.

     Our research aims to dissect the pathways of intercommunication between the microbiota, helminths, and the mammalian immune system at mucosal surfaces such as the intestinal tract. We study how these interactions can influence immune system development and function during homeostasis and in the context of different environmental exposures, such as different diets or exposure to infections. We are particularly interested in understanding how these interactions can impact intestinal and systemic diseases.

     Our ultimate goal is to identify molecules and cellular mechanisms that can influence immune system functioning, which could then be targeted therapeutically to treat or prevent allergic, inflammatory, and infectious diseases.

Our major research questions:

– How do helminths and the microbiota manipulate the intestinal environment, and what are the consequences of this for the mammalian immune system and overall health?

– What mechanisms support oral tolerance development towards dietary/intestinal luminal antigens during postnatal development, and what environmental factors can disrupt oral tolerance leading to allergic sensitization?

– What are the functions of eosinophils in homeostatic conditions, and what environmental factors and signals regulate eosinophil functions?

Memberships and society involvement

We are involved with the following organizations:

Host-Parasite Interactions Research Training Network