IALH Research Fellow Marie-Ève Tremblay has co-authored a new research article entitled Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine. Collaborating authors include Stefano Garofalo, Germana Cocozza, Alessandro Mormino, Giovanni Bernardini, Eleonora Russo, Donald Ielpo, Diego Andolina, Rossella Ventura, Katiuscia Martinello, Massimiliano Renzi, Sergio …
Tag Archives: Marie-Ève Tremblay
ARG1-Expressing Microglia Show a Distinct Molecular Signature and Modulate Postnatal Development and Function of the Mouse Brain
IALH Research Fellow Marie-Ève Tremblay co-authored a research article entitled ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain. Collaborating authors include Vassilis Stratoulias, Rocío Ruiz, Shigeaki Kanatani, Ahmed M. Osman, Lily Keane, Jose A. Armengol, Antonio Rodríguez-Moreno, Adriana-Natalia Murgoci, Irene García-Domínguez, Isabel Alonso-Bellido, Fernando González Ibáñez, …
Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell
IALH Research Fellow Marie-Eve Tremblay (Division of Medical Sciences) has co-authored a new research article entitled Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell. Collaborating authors include Iasonas Dermitzakis, Maria Eleni Manthou, Soultana Meditskou, Steven Petratos, Lida Zoupi, Marina Boziki, Evangelia Kesidou, Constantina Simeonidou, and Paschalis Theotokis. The article …
The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring
IALH Research Fellow Marie-Ève Tremblay and IALH Student Affiliate Collin Murray have co-authored a new research article entitled The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring. Collaborating authors include Sophia M. Loewen, Adriano M. Chavesa, Marianela E. Traetta, Sophia E. Burns, and Keelin H. …
Astrocytes Display Ultrastructural Alterations and Heterogeneity in the Hippocampus of Aged APP-PS1 Mice and Human Post-Mortem Brain Samples
IALH Research Fellow and co-lead of IALH’s Brain Health Research cluster Marie-Ève Tremblay has co-authored a new research article entitled Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples. Collaborating authors include Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Marie-Josée Wallman, and Martin Parent. …
An Aging, Pathology Burden, and Glial Senescence Build-Up Hypothesis for Late Onset Alzheimer’s Disease
IALH Research Fellow Marie-Ève Tremblay and IALH Student Affiliate Victor Lau have co-authored a new research article with Leanne Ramer, entitled An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease. The article was published in Nature Communications. Abstract: Alzheimer’s disease (AD) predominantly occurs as a late onset (LOAD) form involving …
Microglial Diversity Along the Hippocampal Longitudinal Axis Impacts Synaptic Plasticity in Adult Male Mice Under Homeostatic Conditions
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new research article entitled Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Collaborating authors include E. De Felice, E. Gonçalves de Andrade, M. T. Golia, F. González Ibáñez, M. Khakpour, M. A. Di Castro, S. Garofalo, …
Prenatal Inflammation Shapes Microglial Immune Response into Adulthood
Publication alert! IALH Research Fellow Marie-ÈveTremblay has co-authored a research article entitled Prenatal inflammation shapes microglial immune response into adulthood with Marianela E.Traetta. The article was published in Trends in Immunology. Abstract: Hayes and collaborators recently unraveled that maternal immune activation in mice led to a long-lasting decrease in microglial immune reactivity. Thus, microglia exhibited …
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Plasmalogens and Platelet-Activating Factor Roles in Chronic Inflammatory Diseases
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new research article entitled Plasmalogens and Platelet-Activating Factor Roles in Chronic Inflammatory Diseases with Zakaria A. Almsherqi and Yuru Deng. The article was published in BioFactors. Abstract: Fatty acids and phospholipid molecules are essential for determining the structure and function of cell membranes, and they …
Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy Image
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new protocol entitled Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy Images with collaborating authors Marie-Kim St-Pierre, Eva Šimončičová and Micaël Carrier. The protocol was published in Alzheimer’s Disease (pp 63–85). Abstract: In this protocol, we describe the specific steps …
The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics
Publication alert! IALH Research Fellow Eve Tremblay has co-authored a new research article entitled The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics. Collaborating authors include Jared VanderZwaag, Torin Halvorson, Kira Dolhan, Eva Šimončičová, and Benneth Ben-Azu. The article was published in Neurochemical Research. Abstract: There …
Microglia States and Nomenclature: A Field At Its Crossroads
Publication alert! IALH Research Fellow Marie-Eve Tremblay has co-authored a new book chapter entitled Microglia States and Nomenclature: A Field At Its Crossroads. Other authors include Rosa C.Paolicelli, Amanda Sierra, Beth Stevens, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik …
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Microglial Homeostasis Disruption Modulates Non-Rapid Eye Movement Sleep Duration and Neuronal Activity in Adult Female Mice
Publication alert! IALH Research Fellow Marie-ÈveTremblay has co-authored a new research article entitled Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice. Other authors include Katherine Picard, Giorgio Corsi, Fanny Decoeur, Maria Amalia Di Castro, Maude Bordeleau, Marine Persillet, Sophie Layé, Cristina Limatola, and Agnès Nadjar. The article …
A 3D Analysis Revealed Complexe Mitochondria Morphologies in Porcine Cumulus Cells
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new research article entitled A 3D analysis revealed complexe mitochondria morphologies in porcine cumulus cells. Other authors include Amel Lounas, Ariane Lebrun, Isabelle Laflamme, Nathalie Vernoux, Julie Savage, Marc Germain & François J. Richard. The article was published in Scientific Reports. Abstract: In the ovarian …
The Future of Neuroimmunology Research for CNS Disease Therapeutics
Promising pharmacological targets and drug approaches for the treatment of diseases of the central nervous system (CNS) are emerging. Jerry Madukwe, the Editor-in-Chief of Trends in Pharmacological Sciences asked authors of the August 2022 special issue to reflect on the global challenges in the field and what they see as the future of neuroimmunology research …
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Density of TMEM119-Positive Microglial Cells in Postmortem Cerebrospinal Fluid as a Surrogate Marker for Assessing Complex Neuropathological Processes in the CNS
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new research article entitled Density of TMEM119-positive microglial cells in postmortem cerebrospinal fluid as a surrogate marker for assessing complex neuropathological processes in the CNS. Other authors include Simone Bohnert, Stefanie Trella, Ulrich Preiß, Helmut Heinsen, Michael Bohnert, Johann Zwirner, Camelia-Maria Monoranu and Benjamin Ondruschka. …
Manual versus automatic analysis of microglial density and distribution: a comparison in the hippocampus of healthy and lipopolysaccharide-challenged mature male mice
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new research article entitled Manual versus automatic analysis of microglial density and distribution: a comparison in the hippocampus of healthy and lipopolysaccharide-challenged mature male mice. Other authors include Mohammadparsa Khakpour, Fernando González Ibáñez, Maude Bordeleau, Katherine Picard, Leo Mckee-Reid, Benneth Ben-Azu and Laura Maggi. The …
Blocking Immune Cell Infiltration of the Central Nervous System to Tame Neuroinflammation in Amyotrophic Lateral Sclerosis
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a research article entitled Blocking immune cell infiltration of the central nervous system to tame Neuroinflammation in Amyotrophic lateral sclerosis. Other authors include Stefano Garofalo, Germana Cocozza, Giovanni Bernardini, Julie Savage, Marcello Raspa, Eleonora Aronica, Richard M. Ransohoff, Angela Santoni, and Cristina Limatola. The article was …
Microglia as a Hub for Suicide Neuropathology: Future Investigation and Prevention Targets
[et_pb_section fb_built=”1″ admin_label=”section” _builder_version=”4.16″ global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row admin_label=”row” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||” theme_builder_area=”post_content”][et_pb_text admin_label=”Text” _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” global_colors_info=”{}” theme_builder_area=”post_content”]Publication Alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new research article entitled Microglia as a Hub for Suicide Neuropathology: Future Investigation and Prevention Targets. Other authors include Elisa …
Present and Future of Microglial Pharmacology
Publication Alert! IALH Research Fellow Marie-Ève Tremblay has a review published in Trends in Pharmacological Sciences. The review is entitled “Present and future of microglial pharmacology”. Other authors include Eva Šimončičová, Elisa Gonçalves de Andrade, Haley A. Vecchiarelli, Ifeoluwa O.Awogbindin and Charlotte I.Delage. Highlights: Distinct microglial morphological, ultrastructural, and molecular states contribute contextually relevant functions …
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Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring
Publication Alert! IALH Research Fellow Marie-Ève Tremblay has published an article entitled “Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring.” Co-authors include Maude Bordeleau, Cesar H. Comin, Lourdes Fernández de Cossío, Chloé Lacabanne, Moises Freitas-Andrade, Fernando González Ibáñez, Joanna Raman-Nair, Michael Wakem, Mallar Chakravarty, Luciano da F. Costa and …