Publication Alert! IALH Research Fellow Marie-Ève Tremblay has a review published in Trends in Pharmacological Sciences. The review is entitled “Present and future of microglial pharmacology“. Other authors include Eva Šimončičová, Elisa Gonçalves de Andrade, Haley A. Vecchiarelli, Ifeoluwa O.Awogbindin and Charlotte I.Delage.
Highlights:
Distinct microglial morphological, ultrastructural, and molecular states contribute contextually relevant functions across health and disease.
Current microglia-related therapies, including minocycline, cytokine receptor antibodies, modulators of complement, purinergic receptors, fractalkine, colony stimulating factor1 receptor (CSF1R), and triggering receptor expressed on myeloid cells 2 (TREM2) improve the brain inflammatory balance; however, they lack selectivity on the level of microglia and/or myeloid cells needed to avoid off-targets.
Careful application of systemic approaches can be insightful in respect to previously less investigated microglial targets such as endocannabinoids or energetic metabolism modulators.
Emerging knowledge on microglial heterogeneity provides opportunity for the development of selective modulators of beneficial and/or aberrant microglial functions in a context-dependent manner.
To read the full review, see https://doi.org/10.1016/j.tips.2021.11.006