IALH Research Fellow Stephanie Willerth (Engineering) has co-authored a new research article entitled hiPSC-derived GRN-deficient astrocytes delay spiking activity of developing neurons. Collaborating authors include Christopher Lee, Jonathan Frew, Nicholas L. Weilinger, Stefan Wendt, Wenji Cai, Stefano Sorrentino, Xiujuan Wu, Brian A. MacVicar, and Haakon B. Nygaard. The article was published in Neurobiology of Disease. …
Category Archives: Brain Health
ARG1-Expressing Microglia Show a Distinct Molecular Signature and Modulate Postnatal Development and Function of the Mouse Brain
IALH Research Fellow Marie-Ève Tremblay co-authored a research article entitled ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain. Collaborating authors include Vassilis Stratoulias, Rocío Ruiz, Shigeaki Kanatani, Ahmed M. Osman, Lily Keane, Jose A. Armengol, Antonio Rodríguez-Moreno, Adriana-Natalia Murgoci, Irene García-Domínguez, Isabel Alonso-Bellido, Fernando González Ibáñez, …
Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell
IALH Research Fellow Marie-Eve Tremblay (Division of Medical Sciences) has co-authored a new research article entitled Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell. Collaborating authors include Iasonas Dermitzakis, Maria Eleni Manthou, Soultana Meditskou, Steven Petratos, Lida Zoupi, Marina Boziki, Evangelia Kesidou, Constantina Simeonidou, and Paschalis Theotokis. The article …
Stress and Traumatic Brain Injury: An Inherent Bi-Directional Relationship with Temporal and Synergistic Complexities
IALH Research Fellows Jodie Gawryluk and Brian Christie have co-authored a new research article entitled Stress and traumatic brain injury: An inherent bi-directional relationship with temporal and synergistic complexities. Collaborating authors include Justin Brand, Stuart J. MacDonald and Sandy R. Shultz. The article was published in Neuroscience & Biobehavioral Reviews. Abstract: Traumatic brain injury …
Women are Taking the Hit: Examining the Unique Consequences of Cannabis Use Across the Female Lifespan
IALH Research Fellow Brian Christie has co-authored a new research article entitled Women are Taking the Hit: Examining the Unique Consequences of Cannabis Use Across the Female Lifespan. Collaborating authors include E.L. Gräfe, H.M.O. Reid, I. Shkolnikov, K. Conway, A. Kit, and C. Acosta. The article was published in Frontiers in Neuroendocrinology. Abstract: Cannabis use …
The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring
IALH Research Fellow Marie-Ève Tremblay and IALH Student Affiliate Collin Murray have co-authored a new research article entitled The Outcomes of Maternal Immune Activation Induced with the Viral Mimetic Poly I:C on Microglia in Exposed Rodent Offspring. Collaborating authors include Sophia M. Loewen, Adriano M. Chavesa, Marianela E. Traetta, Sophia E. Burns, and Keelin H. …
Intravenous Reelin Treatment Rescues Atrophy of Spleen White Pulp and Correlates to Rescue of Forced Swim Test Immobility and Neurochemical Alterations Induced by Chronic Stress
IALH Research Fellow Hector Caruncho and IALH Student Affiliate Brady Rieve have co-authored a new research article entitled Intravenous Reelin Treatment Rescues Atrophy of Spleen White Pulp and Correlates to Rescue of Forced Swim Test Immobility and Neurochemical Alterations Induced by Chronic Stress. Collaborating authors include Jenessa N. Johnston, Carla L. Sánchez-Lafuente, Lucy Zhang, Aland …
Astrocytes Display Ultrastructural Alterations and Heterogeneity in the Hippocampus of Aged APP-PS1 Mice and Human Post-Mortem Brain Samples
IALH Research Fellow and co-lead of IALH’s Brain Health Research cluster Marie-Ève Tremblay has co-authored a new research article entitled Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples. Collaborating authors include Marie-Kim St-Pierre, Micaël Carrier, Fernando González Ibáñez, Mohammadparsa Khakpour, Marie-Josée Wallman, and Martin Parent. …
An Aging, Pathology Burden, and Glial Senescence Build-Up Hypothesis for Late Onset Alzheimer’s Disease
IALH Research Fellow Marie-Ève Tremblay and IALH Student Affiliate Victor Lau have co-authored a new research article with Leanne Ramer, entitled An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease. The article was published in Nature Communications. Abstract: Alzheimer’s disease (AD) predominantly occurs as a late onset (LOAD) form involving …
Brain Art Competition and Showcase 2023
The Institute on Aging and Lifelong Health’s Brain Health Research Cluster is hosting a Brain Art Competition and Showcase. The goals of the event are to: Bridge science and art Encourage creative approaches to visualizing what brain health means Call for submissions is now open! Submissions must be focused on the brain, inspired by research, and original. …
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
IALH Research Fellow Brian Christie has co-authored a new research article entitled Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury. Collaborating authors include Allyson Gross, Annika Willoughby, Erin Grafe, Justin Brand, Emily Bosdachin, Hannah M. O. Reid, Crystal Acosta, and Eric Eyolfson. The article was published in …
Brief Diesel Exhaust Exposure Acutely Impairs Functional Brain Connectivity in Humans: A Randomized Controlled Crossover Study
IALH Research Fellow Jodie Gawryluk and IALH Student Affiliate Ashleigh Parker have co-authored a research article entitled Brief diesel exhaust exposure acutely impairs functional brain connectivity in humans: a randomized controlled crossover study. Collaborating authors include Daniela J. Polombo, Jason Curran, and Chris Carlsten. The article was published in Environmental Health: A Global Access Science …
A Scoping Review of Rodent Studies Investigating the Epigenetic Mechanisms in the Brain Underlying the Effects of Diet on Depressive-like Behaviour
Publication alert! IALH Research Fellow Hector Caruncho and IALH Student Affiliate Brady Rieve have co-authored a new research article entitled A Scoping Review of Rodent Studies Investigating the Epigenetic Mechanisms in the Brain Underlying the Effects of Diet on Depressive-like Behaviour. Collaborating authors include Carla Sánchez-Lafuente, and Lisa Kalynchuck. The article was published in Biomedicines. …
Microglial Diversity Along the Hippocampal Longitudinal Axis Impacts Synaptic Plasticity in Adult Male Mice Under Homeostatic Conditions
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new research article entitled Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Collaborating authors include E. De Felice, E. Gonçalves de Andrade, M. T. Golia, F. González Ibáñez, M. Khakpour, M. A. Di Castro, S. Garofalo, …
Prenatal Inflammation Shapes Microglial Immune Response into Adulthood
Publication alert! IALH Research Fellow Marie-ÈveTremblay has co-authored a research article entitled Prenatal inflammation shapes microglial immune response into adulthood with Marianela E.Traetta. The article was published in Trends in Immunology. Abstract: Hayes and collaborators recently unraveled that maternal immune activation in mice led to a long-lasting decrease in microglial immune reactivity. Thus, microglia exhibited …
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Plasmalogens and Platelet-Activating Factor Roles in Chronic Inflammatory Diseases
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new research article entitled Plasmalogens and Platelet-Activating Factor Roles in Chronic Inflammatory Diseases with Zakaria A. Almsherqi and Yuru Deng. The article was published in BioFactors. Abstract: Fatty acids and phospholipid molecules are essential for determining the structure and function of cell membranes, and they …
Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy Image
Publication alert! IALH Research Fellow Marie-Ève Tremblay has co-authored a new protocol entitled Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy Images with collaborating authors Marie-Kim St-Pierre, Eva Šimončičová and Micaël Carrier. The protocol was published in Alzheimer’s Disease (pp 63–85). Abstract: In this protocol, we describe the specific steps …
The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics
Publication alert! IALH Research Fellow Eve Tremblay has co-authored a new research article entitled The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics. Collaborating authors include Jared VanderZwaag, Torin Halvorson, Kira Dolhan, Eva Šimončičová, and Benneth Ben-Azu. The article was published in Neurochemical Research. Abstract: There …
Microglia States and Nomenclature: A Field At Its Crossroads
Publication alert! IALH Research Fellow Marie-Eve Tremblay has co-authored a new book chapter entitled Microglia States and Nomenclature: A Field At Its Crossroads. Other authors include Rosa C.Paolicelli, Amanda Sierra, Beth Stevens, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik …
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Longitudinal Change in Daily Stress Across 20 Years of Adulthood: Results From the National Study of Daily Experiences
IALH Research Fellow Jonathan Rush has co-authored a new research article entitled Longitudinal Change in Daily Stress Across 20 Years of Adulthood: Results From the National Study of Daily Experiences. Other authors include David M. Almeida, Jacqueline Mogle, Jennifer R. Piazza, Eric Cerino and Susan T. Charles. The article was published in Developmental …
Sex Differences in Basal Reelin Levels in the Paraventricular Hypothalamus and In Response to Chronic Stress Induced By Repeated Corticosterone in Rats
Publication alert! IALH Research Fellow Hector Caruncho has co-authored a new research article entitled Sex differences in basal reelin levels in the paraventricular hypothalamus and in response to chronic stress induced by repeated corticosterone in rats. Other authors include colleagues from the Division of Medical Sciences at University of Victoria: Carla L. Sánchez-Lafuente, Raquel Romay-Tallon, …
Cardiopulmonary and Cerebrovascular Acclimatization in Children and Adults at 3800 Meters
Publication alert! IALH Research Fellow Kurt Smith has co-authored a new research article entitled Cardiopulmonary and cerebrovascular acclimatization in children and adults at 3800 meters. Other authors include M. G. Rieger, C. M. Tallon, D. R. Perkins, M. Stembridge, S. Piombo, S. Radom-Aizik, D. M. Cooper, P. N. Ainslie, and A. M. McManus. The article …
Choral Singing and Dementia: Exploring Musicality as Embodied and Relational Accomplishment
Publication alert! IALH Research Fellows André P. Smith, Stuart W.S.MacDonald and Debra Sheets have co-authored a new research article with Ruth Kampen and Tara Erb entitled Choral Singing and Dementia: Exploring Musicality as Embodied and Relational Accomplishment. The article was published in Journal of Aging Studies. Abstract: This study explored the impact of participation in …
Microglial Homeostasis Disruption Modulates Non-Rapid Eye Movement Sleep Duration and Neuronal Activity in Adult Female Mice
Publication alert! IALH Research Fellow Marie-ÈveTremblay has co-authored a new research article entitled Microglial homeostasis disruption modulates non-rapid eye movement sleep duration and neuronal activity in adult female mice. Other authors include Katherine Picard, Giorgio Corsi, Fanny Decoeur, Maria Amalia Di Castro, Maude Bordeleau, Marine Persillet, Sophie Layé, Cristina Limatola, and Agnès Nadjar. The article …
Increased Myelination Plays a Central Role in White Matter Neuroplasticity
Publication alert! IALH Research Fellow Jodie Gawryluk has co-authored a new research article entitled Increased myelination plays a central role in white matter neuroplasticity. Other authors include Eric D.Kirby, Tory O.Frizzell, Lukas A.Grajauskas, Xiaowei Song, Bimal Lakhani, Lara Boyd and Ryan C.N. D’Arcy. The article was published in NeuroImage. Abstract: White matter (WM) neuroplasticity in …
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