POSITION
Ph.D. Neuroscience Student
CREDENTIALS
MY RESEARCH INTERESTS
Keywords: neurodevelopment, neuroplasticity, neurodegeneration
How can positive and negative experiences modulate our brain and behavior? For example, think about negative experiences like early stress and positive habits like an active lifestyle! If a more active lifestyle is beneficial for the brain, could it act as a protective factor against a neurodegenerative disease such as Huntington’s disease? On the other hand, could early stress alter the brain to the point of increasing the chances of addiction in the future? Questions like these are difficult to answer by studying humans because each individual’s genetics and experience are unique. However, in the laboratory, genetics and environment can be controlled and then we can answer questions like these and draw parallels with what happens to humans!
PUBLICATIONS
- Plàcido, E.†; Welter, P. G.†; Wink, A. C.; Karasiak, G. D.; Outeiro, T. F.; Dafre, A. L.; Gil-Mohapel, J.; Brocardo, P. S. Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. v.24, p.12607, 2023. doi: 10.3390/ijms241612607. †These authors contributed equally to this work.
- Leal, Rodrigo Bainy; Mann, Josiane; Pinto-Junior, Vanir Reis; Oliveira, Messias Vital; Osterne, Vinicius Jose Silva; Wolin, Ingrid Alessandra Victoria; Nascimento, Ana Paula Machado; Welter, Priscilla Gomes; Ferreira, Valeria Maria Sousa; Silva, Alice Araujo; Seeger, Rodrigo Lopes; Nascimento, Kyria Santiago; Cavada, Benildo Sousa. Structural Prediction and Characterization of Canavalia grandiflora (ConGF) Lectin Complexed with MMP1: Unveiling the Antiglioma Potential of Legume Lectins. v.27, p.7089, 2022. doi: 10.3390/molecules27207089
- de Paula Nascimento-Castro, Cristine; Winkelmann-Duarte, Elisa C.; Mancini, Gianni; Welter, Priscilla Gomes; Plácido, Evelini; Farina, Marcelo; Gil-Mohapel, Joana; Rodrigues, Ana Lúcia S.; De Bem, Andreza Fabro; Brocardo, Patricia S. Temporal Characterization of Behavioral and Hippocampal Dysfunction in the YAC128 Mouse Model of Huntington’s Disease. BIOMEDICINES. v.10, p.1433, 2022. doi: 10.3390/biomedicines10061433
- Wolin, Ingrid A.V.; Heinrich, Isabella A.; Nascimento, Ana Paula M.; Welter, Priscilla G.; Sosa, Liliana Del V.; De Paul, Ana Lucia; Zanotto-Filho, Alfeu; Nedel, Cláudia Beatriz; Lima, Lara Dias; Osterne, Vinicius Jose Silva; Pinto-Junior, Vanir Reis; Nascimento, Kyria S.; Cavada, Benildo S.; Leal, Rodrigo B. ConBr lectin modulates MAPKs and Akt pathways and triggers autophagic glioma cell death by a mechanism dependent upon caspase-8 activation. BIOCHIMIE. v.180, p.186-204, 2021. doi: 10.1016/j.biochi.2020.11.003
- Kim, Amy; Lalonde, Kathryn; Truesdell, Aaron; Gomes Welter, Priscilla; Brocardo, Patricia S.; Rosenstock, Tatiana R.; Gil-Mohapel, Joana. New Avenues for the Treatment of Huntington’s Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. v.22, p.8363, 2021. doi: 10.3390/ijms22168363
- Nascimento, Ana Paula Machado; Wolin, Ingrid Alessandra Victoria; Welter, Priscilla Gomes; Heinrich, Isabella; Zanotto-Filho, Alfeu; Osterne, Vinicius Jose Silva; Lossio, Claudia; Silva, Mayara; Nascimento, Kyria Santiago; Cavada, Benildo Sousa; Leal, Rodrigo Bainy. Lectin from Dioclea violacea induces autophagy in U87 glioma cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. v.134, p.660 – 672, 2019. doi: 10.1016/j.ijbiomac.2019.04.203
- Leal, Rodrigo Bainy; Pinto-Junior, Vanir Reis; Osterne, Vinicius Jose Silva; Wolin, Ingrid Alessandra Victoria; Nascimento, Ana Paula Machado; Neco, Antonio Hadson Bastos; Araripe, David Alencar; Welter, Priscilla Gomes; Neto, Corneville Correia; Correia, Jorge Luis Almeida; Rocha, Cintia Renata Costa; Nascimento, Kyria Santiago; Cavada, Benildo Sousa. Crystal structure of DlyL, a mannose-specific lectin from Dioclea lasiophylla Mart. Ex Benth seeds that display cytotoxic effects against C6 glioma cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. v.114, p.64 – 76, 2018. doi: 10.1016/j.ijbiomac.2018.03.080
- Plácido, Evelini; de Paula Nascimento-Castro, Cristine; Welter, Priscilla Gomes; Gil-Mohapel, Joana; Brocardo, Patricia S. Linking Huntington disease, brain-derived neurotrophic factor, and depressive-like behaviors In: The Neuroscience of Depression.1 ed.: Elsevier, 2021, p. 161-177. doi: 10.1016/B978-0-12-817935-2.00042-8
CONTACT
Contact: priscilla.gomeswelter@gmail.com
OTHER
A fun fact about me: Be careful with me driving a car, I’m a terrible driver! I once went to pick up my boyfriend from his internship and, when parking, I mistook the brake for the accelerator. What was the result? I broke a beautiful flower vase. My boyfriend, who was still inside the building, didn’t see anything but he heard the noise and thought “I think my girlfriend just got here”. He was right!
My hobbies include: Reading, travel, hiking, watch series and movies.